Formulation, optimization and evaluation of losartan potassium microemulsions for treating hypertension
نویسندگان
چکیده
Microemulsions are the advanced form of conventionally used emulsions, which is a biphasic dosage consisting two immiscible liquids that brought together with application surfactants and cosurfactants. The micron sized globules microemulsions helps in achieving targeted action improved availability stability. studies related to concluded its potential delivering various hydrophilic lipophilic drugs several leading manufacturers considering this as ideal formulation for potent via routes including oral, ocular, parenteral, topical routes. advancements occurred during previous few years pharmaceutical sector results identification innovative methods preparing patents preparation granted last decade. This article enlisted basic information microemulsion along component, structure, method evaluation parameters. applications sectors healthcare segment also discussed review future scenario article. Along this, commercially available microemulsion, patent insight list previously by researchers based products.
منابع مشابه
Formulation and Evaluation of Buccoadhesive Films of Losartan Potassium
Buccoadhesive buccal delivery systems for losartan potassium in the form of buccal films were developed and characterized for improving bioavailability. The films were formulated by solvent casting method using different bioadhesive polymers like HPMC, Eudragit RS100, Eudragit RL100 and Ethylcellulose with glycerol as plasticizer. The films were characterized on the basis of their physical char...
متن کاملMouth Dissolving Tablets of Losartan Potassium: Formulation and Evaluation
Losartan potassium is an angiotention receptor antagonist, used in the management of hypertension. The objective of the proposed research work is to prepare and evaluate the mouth dissolving/disintegrating tablets (MDTs) of losartan Potassium, which avoid the first-pass metabolism, improved the dissolution rate and enhance the bioavailability. Mouth dissolving tablets (MDTs) were prepared by di...
متن کاملFormulation, In-vitro Evaluations and Skin Irritation Study of Losartan Potassium Transdermal Patches
Losartan potassium is a well known orally active non-peptide angiotensin II receptor antagonist. Losartan potassium and its principle active metabolites block the vasoconstrictor and aldosterone secreting effect of angiotensin II by selectively blocking the binding of angiotensin II to AT1 receptors. The drug is reported to promote the decrease in ventricular hypertrophy, salt ...
متن کاملFormulation and Evaluation of Microspheres of Losartan Potassium Using Biodegradable Natural Polymers
Present investigation describes preparation of microspheres by solvent evaporation followed by in vitro characterization of microspheres to evaluate the effect of method of preparation on physical properties and drug release profile of microspheres. The microspheres were found to be discrete, spherical with free flowing properties. The morphology (Scanning Electron Microscopy), particle size di...
متن کاملFormulation and in Vitro Evaluation of Losartan Potassium Mucoadhesive Buccal Tablets
Objective: The Losartan potassium mucoadhesive buccal tablet were prepared using mucoadhesive polymers such as Carbopol 940P, pectin, sodium CMC, Sodium alginate, HPMC K4M, HPMC K15M and HPMC K100M in alone and in combination as release retarding agent to prolong the drug release and to avoid first pass metabolism. Methods: The mucoadhesive buccal tablets were prepared by direct compression met...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Health Sciences (IJHS)
سال: 2022
ISSN: ['2550-6978', '2550-696X']
DOI: https://doi.org/10.53730/ijhs.v6ns6.10827